A Phi Beta Kappa graduate of Harvard College (1927) and Harvard Medical School, Solomon served as a Commander in the U.S. Navy attached to the sixth Marine division during World War II as the Division Psychiatrist. He was Clinical Professor of Psychiatry at Harvard Medical School and Physician in Chief of Psychiatry at Boston City Hospital from 1952 until 1969. He founded the College Mental Health Center in Boston in 1968. In 1969, Solomon moved to La Jolla, California where he served as Clinical Professor of Psychiatry at the UCSD Medical School.
Married three times with three children, Dr. Solomon was preceded in death by his first wife, Sarah "Pebbles" Gelman Solomon (of Hartford, Boston, Los Angeles and Houston), his second wife U.S. Senator Maurine Brown Neuberger and survived third ex-wife, Dr. Susan Thurman Kleeman of Boston; son, fine art photographer Andrew L. Solomon, and Andrew's wife, Dana Donsky Solomon, Esq, of Houston; two daughters, music and popular culture critic Linda Solomon of Houston and Susan Thurman Solomon of Boston; stepson, Jeffrey Thurman Kleeman of Los Angeles; grandsons, Rex Solomon, and Rex's wife Margaret Ann Solomon, Esq, and great grandson Dylan Chase Solomon, of Houston, and cinematographer Keith Solomon  and his wife, and two great granddaughters of Los Angeles.
- Consultant, U.S. Nuclear Regulatory Commission, Washington. D.C.
- Chairman of the American Psychiatric Association Committee on Psychiatry and Medical Practice
- Sensory Deprivation: A Symposium (1961) (editor) Template:OCLC
- The Psychiatric Consultation (1968) (editor with Werner M. Mendel) Template:OCLC
- Handbook of Psychiatry (1974) ISBN 0870411640
- Solomon, P.; Patch, V. D.; Sturrock, J.D.; Wexler, D. (1967). "A new approach to student mental health in small colleges". American Journal of Psychiatry 124 (5): 658–661. doi:10.1176/appi.ajp.124.5.658. PMID 6050791.
- Mark's Other Woman, Time, November 5, 1965.
- Andrew L. Solomon Fine Art Photography
- IMDb: Keith Solomon